Dear colleagues,

You are cordially invited to the BioPhysLab seminar, which will be held on Tuesday, December 10th 2024 at 11:30h in the library reading room “Dr. Dragan Popović" of the Institute of Physics Belgrade. The talk entitled

"Nagging cells to death"

will be given by Prof. Andrew H.A. Clayton, Academic Director for Research Training, School of Science, Computing and Engineering Technologies, Swinburne University of Technology,  Melbourne, Australia. 

Abstract of the talk:

Recent advancements in optogenetics and microfluidics have made possible the exciting new branch of synthetic biology, where inputs to cells can be controlled in space and time. While in some instances the goal is to replicate normal physiology (e.g. calcium oscillations) in other cases the use of synthetic, non-physiological inputs provides information on how cells sense and interpret dynamic environments. In our laboratory we have been using microfluidic approaches to investigate how the frequency of growth factor inputs affects cell behaviour-cell proliferation, cell population decline and cell differentiation. Interestingly epidermal growth factor, a hormone that normally promotes cell survival and proliferation can induce cell population decline at certain frequencies and induce premature differentiation at others. We propose that the intracellular enzyme cascades (ERK, CREB, JNK, AKT) that control different cell outcomes have distinct growth factor driven activation kinetics, which endows them with different band-pass filtering characteristics.

References:

Nguyen H N Tran and Andrew H A Clayton, Transfer function approach to understanding periodic forcing of signal transduction networks, 2023 Phys. Biol. 20 035001

Zubaidah Ningsih and Andrew H A Clayton, Does frequency-dependent cell proliferation exhibit a Fano-type resonance? 2020 Phys. Biol. 17 044001

Sincerely, 

--

dr Aleksandar J. Krmpot, naucni savetnik
BioPhysLab
Institut za fiziku, Pregrevica 118, 11080 Beograd-Zemun, SRBIJA

dr. Aleksandar J. Krmpot, research professor
BioPhysLab
Institute of Physics, Pregrevica 118, 11080 Belgrade- Zemun, SERBIA

telefon/phone:  +381 11 3713 012
mobilni/cell:   +381 64 202 65 62
e-posta/e-mail: krmpot@ipb.ac.rs
www.hemmaginero.rs 
www.ipb.ac.rs 
http://www.ipb.ac.rs/en/istrazivanja/laboratorije-2/laboratorija-za-biofiziku/