[institut] Predavanje

[Tasko Grozdanov]

CENTAR ZA TEORIJSKU FIZIKU

U sredu, 26.09.2012. sa početkom u 14 časova u sali bibliteke Instituta za
fiziku održaće se predavanje:

 

CHALLENGES IN SINGLE-MOLECULE DNA SEQUENCING

Predrag S. Krstic, 

TheoretiK Consulting, Knoxville , TN, USA

Joint Institute of Computational Sciences, University of Tennessee  & Oak
Ridge National Laboratory, Oak Ridge, TN, USA

Department for Physics and Astronomy, University of Tennessee, Knoxville,
TN, USA

 

The main challenges of the so called physical approaches to DNA sequencing,
based on the reading of electrical signals associated to the DNA bases while
a single DNA polymer is translocated through the synthetic nanopore [1], are
twofold: (1) electric signal-to-noise ratio that distinguishes between the
DNA bases and (2) full control and localization of a DNA in the
nanoelectrode  gap or nanopore. We study both issues for  various  types of
the  nanopore  technologies (carbon nanotubes, silicon nanopores and  linear
quadrupole , aqueous  nanotraps), by multiscale  theoretical approaches,
ranging  from  quantum mechanical , quantum-classical and classical
molecular dynamics, to continuum fluid dynamics. Our results are validated
by experiments at Arizona State University [2,3] (Stuart Lindsay) and  Yale
University [4,5] (Mark Reed). This talk will discuss problems and possible
solutions for DNA translocation and tunneling recognition with electrode
functionalization in presence of thermal fluctuations, viscosity,
electrophoretic, dielectrophotretic and electroosmotic  forces.  

[1] Branton D et al,  NATURE BIOTECHNOLOGY  26, 1146-1153  (2008).

[2]   Liu HT et al, , SCIENCE, 327(5961), 68  (2010).

[3] P. Pang et al, , ACS NANO  5 (9), 7277-7283 (2011).

[4] W. Guan et al, ,  PNAS  108 (23),  9326-9330 (2011).

[5] Park, J. H. et al,  SMALL 8, 907 (2012).

 

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