[institut] Change of Room and Reminder - SCL Seminar: Stefan Milenković, Friday, 27 December, 11:00

[Nenad Vukmirović]

Dear colleagues,

This is a reminder for the seminar that will be held today at 11:00. 
Please also note that there was a change of the room. The seminar will 
be held in the "Zvonko Marić" hall.

Best regards,
Nenad Vukmirović.




-------- Forwarded Message --------
Subject:     SCL Seminar: Stefan Milenković, Friday, 27 December, 11:00
Date:     Fri, 20 Dec 2019 10:34:08 +0100
From:     Nenad Vukmirovic <nenad.vukmirovic at ipb.ac.rs>
To:     institut at ipb.ac.rs, nastavnici at ff.bg.ac.rs, office at vin.bg.ac.rs, 
all at aob.rs
CC:     scl-all at scl.rs



Dear colleagues,

You are cordially invited to the SCL seminar of the Center for the Study 
of Complex Systems, which will be held on Friday, 27 December 2019 at 
11:00 in the "Zvonko Marić" hall of the Institute of Physics Belgrade. 
The talk entitled

Sodium transport in mammalian two-pore channels

will be given by Dr Stefan Milenković (University of Cagliari, Italy). 
Abstract of the talk:

Although being in focus in the last decades, two-pore channels (TPCs) 
remain partially comprehended. Their importance for vacuolar (plants) 
and organellar (animals) function highlights them as a very attractive 
to study, both theoretically and experimentally. A particular boost for 
theoretical examinations has been made with recent, high-resolution 
x-ray and cryo-EM structures. These findings have enabled for efficient 
and precise computational studies at atomistic level. Here we report a 
set of simulations performed on a mammalian TPC1, a voltage and ligand 
gated sodium selective channel. The simulations were used for a thorough 
analysis of the TPC1 behavior in presence and absence of ligand 
(PtdIns(3,5)P2), with a special accent on the TPC1’s bottleneck, 
hydrophobic (HF) gate. Moreover, we have described a potential passage 
of sodium ions through the HF gate by means of metadynamics (MTD) 
simulations and estimated the sodium conductance. Estimated 
computationally, this conductance is in excellent agreement with its 
experimental value.

Best regards,
Nenad Vukmirović

-- 
Dr Nenad Vukmirović
Research Professor
Scientific Computing Laboratory
Center for the Study of Complex Systems
Insitute of Physics Belgrade
Pregrevica 118, 11080 Belgrade, Serbia
URL: http://www.scl.rs/nenad
-- 
др Ненад Вукмировић
научни саветник
Лабораторија за примену рачунара у науци
Институт за физику у Београду
Србија
URL: www.scl.rs/nenad