[institut] Reminder - Photonics Center Seminar, Tuesday, 09. 06. 2026. at 13h

[Mihailo Rabasovic]

Dear colleagues, 

You are kindly invited to the Photonics center seminar, which will be
held on Tuesday, 09. 06. 2026. at 13h, in the "Dragan Popović" hall. The
Laboratory for nanophotonics will be presented at the seminar. Marija
Radmilovic-Radjenovic will tell us something about the lab, and Nikola
Boskovic will give a seminar entitled: 

Numerical Modeling of Radiofrequency Ablation of Tumors Using
Heterogeneous Porous Tissue Models 

The seminar abstract is below in the e-mail. 

Best regards,
Mihailo Rabasović 

Abstract
Radiofrequency ablation (RFA) is one of the most widely used minimally
invasive methods for the local destruction of tumor tissue using
high-frequency electrical current. Treatment success depends on numerous
parameters, including the electrical and thermal properties of the
tissue, tumor geometry, blood perfusion, and the spatial heterogeneity
of the biological environment. Due to the complexity of these processes,
numerical modeling serves as a significant tool for the analysis and
optimization of ablative procedures. 

The simulation employs a three-dimensional RFA model developed using
open-source finite element method (FEM) software. The model encompasses
the electrical calculation of potential and electric field distribution
within the tissue, the computation of heat generation via Joule heating,
and a time-dependent analysis of heat transfer and thermal necrosis
development. Particular attention is dedicated to modeling the tumor as
a heterogeneous porous medium, where porosity varies continuously within
the tumor volume in accordance with the physiological characteristics of
the tissue. 

The developed model enables the analysis of the impact of spatial
porosity distribution on temperature fields, tissue damage dynamics, and
changes in electrical conductivity during ablation. The results
demonstrate that the heterogeneous structure of the tumor can
significantly influence both the morphology and dimensions of the
necrosis zone, as well as the distribution of electrical energy within
the treated region. These findings underscore the importance of
incorporating realistic biophysical parameters into numerical models,
representing a crucial step toward the development of personalized
systems for planning and optimizing ablative therapies. 

A specific contribution of this work is the introduction of a continuous
spatial porosity distribution within the tumor and the subsequent
analysis of its impact on the electro-thermal behavior of the tissue
during ablation. This approach enables a more realistic representation
of the complex microstructure of tumor tissue compared to conventional
homogeneous models, thereby opening the possibility for the development
of advanced, simulation-based personalized therapy protocols.
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