[phys4phys] BioPhysLab seminar: Prof. Andrew H.A. Clayton, Tuesday, December 10th 2024, 11:30h

[Aleksandar Krmpot]

Dear colleagues,

You are cordially invited to the BioPhysLab seminar, which will be held
on Tuesday, December 10th 2024 at 11:30h in the library reading room
"Dr. Dragan Popović" of the Institute of Physics Belgrade. The talk
entitled

"Nagging cells to death"

will be given by Prof. Andrew H.A. Clayton, Academic Director for
Research Training, School of Science, Computing and Engineering
Technologies, Swinburne University of Technology,  Melbourne, Australia.
 

Abstract of the talk: 

Recent advancements in optogenetics and microfluidics have made possible
the exciting new branch of synthetic biology, where inputs to cells can
be controlled in space and time. While in some instances the goal is to
replicate normal physiology (e.g. calcium oscillations) in other cases
the use of synthetic, non-physiological inputs provides information on
how cells sense and interpret dynamic environments. In our laboratory we
have been using microfluidic approaches to investigate how the frequency
of growth factor inputs affects cell behaviour-cell proliferation, cell
population decline and cell differentiation. Interestingly epidermal
growth factor, a hormone that normally promotes cell survival and
proliferation can induce cell population decline at certain frequencies
and induce premature differentiation at others. We propose that the
intracellular enzyme cascades (ERK, CREB, JNK, AKT) that control
different cell outcomes have distinct growth factor driven activation
kinetics, which endows them with different band-pass filtering
characteristics. 

References: 

Nguyen H N Tran and Andrew H A Clayton, Transfer function approach to
understanding periodic forcing of signal transduction networks, 2023
_Phys. Biol._ 20 035001 

Zubaidah Ningsih and Andrew H A Clayton, Does frequency-dependent cell
proliferation exhibit a Fano-type resonance? 2020 _Phys. Biol._ 17
044001 

Sincerely,  

--

dr Aleksandar J. Krmpot, naucni savetnik
BioPhysLab
Institut za fiziku, Pregrevica 118, 11080 Beograd-Zemun, SRBIJA

dr. Aleksandar J. Krmpot, research professor
BioPhysLab
Institute of Physics, Pregrevica 118, 11080 Belgrade- Zemun, SERBIA

telefon/phone:  +381 11 3713 012
mobilni/cell:   +381 64 202 65 62
e-posta/e-mail: krmpot at ipb.ac.rs
www.hemmaginero.rs [1] 
www.ipb.ac.rs [2] 
http://www.ipb.ac.rs/en/istrazivanja/laboratorije-2/laboratorija-za-biofiziku/

 

Links:
------
[1] http://www.hemmaginero.rs
[2] http://www.ipb.ac.rs
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